[Bacteriological correlation of urinary stones and preoperative urine culture: Is there a significant impact on postoperative infectious risk? (Moroccan experience)]. / Corrélation bactériologique entre les calculs urinaires et l'ECBU préopératoire : a-t-il un impact sur le risque infectieux postopératoire ? (expérience marocaine).

AIM: The objectives of this study were to evaluate the impact of preoperative urine culture and the infected nature of stones on the occurrence of postoperative urinary sepsis. MATERIAL AND METHODS: A prospective monocentric study included 29 patients operated on for urolithiasis between January and June 2018. RESULTS: Postoperative urinary sepsis was observed in 4 patients (14%). Urinary colonization rate on preoperative CBU exam was 27.6% (8 of 29) while the rate of colonized stones was 31% (9 of 29). The occurrence of urinary sepsis was observed in 37.5% (3 of 8) of patients with urinary colonization, compared to 44.4% of patients with colonized stones (4 of 9). By comparing the bacteriological results observed during sepsis, the germs isolated in postoperative urine were the same found in the culture of stones. The chemical nature of the colonized stones was mainly calcium oxalate (monohydrate, dihydrate) P=0.02. There was a statistically significant correlation between the preoperative urine culture, the bacteriological culture of stones and the postoperative urinary sepsis (P=0.05, P=0.005) respectively. CONCLUSION: Our study demonstrated a strong association between the bacteriological culture of stones and postoperative urinary sepsis superior to preoperative urine culture. It makes it possible to anticipate the occurrence of sepsis in patients requiring many endoscopic treatments. However, several multicentric prospective series may prove necessary to validate these results. LEVEL OF EVIDENCE: 3.

A systematic review of contemporary management of oligometastatic prostate cancer: fighting a challenge or tilting at windmills?

PURPOSE: Amongst the unanswered questions regarding prostate cancer (PCa), the optimal management of oligometastatic disease remains one of the major concerns of the scientific community. The very existence of this category is still subject to controversy. Aim of this systematic review is to summarize current available data on the most appropriate management of oligometastatic PCa. EVIDENCE ACQUISITION: All relevant studies published in English up to November the 1st were identified through systematic searches in PubMed, EMBASE, Cochrane Library, CINAHL, Google Scholar and Ovid database. A search was performed including the combination of following words: (prostate cancer) and (metastatic) and [(oligo) or (PSMA) or (cytoreductive) or (stereotaxic radiotherapy) or (prostatectomy)]. 3335 articles were reviewed. After title screening and abstract reading, 118 papers were considered for full reading, leaving a total of 36 articles for the systematic review. EVIDENCE SYNTHESIS: There is still no consensus on the definition of oligometastatic disease, nor on the imaging modalities used for its detection. While retrospective studies suggest an added benefit with the treatment the primitive tumor by cytoreductive prostatectomy (55% survival rate vs 21%, p < 0.001), prospective studies do not validate the same outcome. Nonetheless, most studies have reported a reduction in local complications after cytoreductive prostatectomy (< 10%) compared to the best systemic treatment (25-30%). Concerning radiotherapy, an overall survival benefit for patients with a low metastatic burden was found in STAMPEDE (HR 0.68, 95% CI 0.52-0.90; p = 0.007) and suggested in subgroup analysis of the HORRAD trial. Regarding the impact of metastases-directed therapy (MDT), the STOMP and ORIOLE trials suggested that metastatic disease control might improve androgen deprivation therapy-free survival (in STOMP: 21 vs 13 months for MDT vs standard of care). Nonetheless, the impact of MDT on long-term oncologic results remains unclear. Finally, oligometastatic disease appears to be a biologically different entity compared to high-burden metastatic disease. New findings on exosomes appear to make them intriguing biomarkers in the early phases of oligometastatic PCa. CONCLUSION: Oligometastatic PCa is today a poorly understood disease. The implementation of new imaging techniques as whole-body MRI and PSMA PET/CT has increased exponentially the number of oligometastatic patients detected. Data of available trials suggest a benefit from cytoreductive prostatectomy to reduce local complication, though its impact on survival remains unknown. Radiotherapy may be beneficial for patients with low-burden metastatic PCa, while MDT may delay the need for androgen deprivation therapy. Results from ongoing trials data are eagerly awaited to draw reliable recommendations.

Traitement des sténoses de l'urètre par urétrotomie interne endoscopique: résultats anatomiques et fonctionnels d'une série de 244 cas

Evaluer les résultats d'une série homogène de sténoses urétrales traitées de façon univoque par urétrotomie interne endoscopique (UIE) et d'étudier les éléments à valeur prédictive du résultat.Patients et méthodes. Entre 1989 et 2007, 244 patients ont été hospitalisés pour sténose de l'urètre. Ils ont bénéficié d'une UIE sous contrôle de la vue. Résultats.Il y a eu 34,3% de bons résultats après la première UIE. Le recul moyen était de 3,5 ans. La mortalité était nulle et la morbidité était évaluée à 5%. Le résultat était d'autant meilleur que le geste concernait une sténose courte (inférieure à 2 cm), unique sur l'urètre proximal. La durée moyenne du cathétérisme post-opératoire a été de 2 jours; maintenir ce cathétérisme au delà n'a pas apporté d'amélioration significative. Les mauvais résultats (65,6%) ont été rapportés dans les cas de sténose étendue, siégeant sur l'urètre distal ou concernant des patients âgés. 62,5% ont été guéris après une deuxième urétrotomie, les autres cas ont nécessité des séances de dilatations urétrales d'entretien, voire un geste de plastie. Conclusion. L'UIE est une intervention simple, dépourvue de morbidité majeure et ne nécessitant qu'une hospitalisation courte. Avec un taux de succès stable de l'ordre de 75,4% à 3,5 ans, il nous paraît licite de proposer l'UIE en première intention pour toute sténose urétrale courte, unique, proximale et qu'elle survient chez un sujet jeune, sans antécédents urétraux

[Prostatic chronic lymphocytic leukemia. Report of 2 cases]. / Localisation prostatique de la leucémie lymphoïde chronique. A propos de 2 cas.

Infiltration of the prostate is frequent in the course of leukaemia. It is usually asymptomatic or may present in the form of classical bladder neck obstruction. The diagnosis is generally established during investigation of the prostate by biopsy or during treatment by resection. The authors report two cases of prostatic involvement in chronic lymphocytic leukaemia.